| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925439 | Archives of Biochemistry and Biophysics | 2013 | 8 Pages |
Abstract
⺠Reaction specificity of lipoxygenases (LOX) is crucial for their biological roles. ⺠5-LOX acts pro-inflammatory but 15-LOX exhibits anti-inflammatory properties. ⺠5-LOX can be converted to 15-LOX by site directed mutagenesis. ⺠Reduction of the active site volume is discussed as basis for this alteration.
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Authors
Katharina Hofheinz, Kumar Reddy Kakularam, Susan Adel, Monika Anton, Aparoy Polymarasetty, Pallu Reddanna, Hartmut Kuhn, Thomas Horn,