Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1925473 | Archives of Biochemistry and Biophysics | 2012 | 9 Pages |
Abstract
⺠Physical basis of intrinsic disorder for function remains to be established. ⺠Detailed characterization of dynamic conformational ensembles of IDPs is necessary. ⺠Integrated computational and experimental strategies are the most effective. ⺠Induced folding-like mechanisms appear to be prevalent in IDP recognition. ⺠Efficient folding upon encounter is required for fast IDP association kinetics.
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Authors
Jianhan Chen,