| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925488 | Archives of Biochemistry and Biophysics | 2012 | 13 Pages |
Abstract
⺠pH tightly modulates oligomerization of BclXL. ⺠Acidic pH promotes the assembly of BclXL into a megadalton oligomer. ⺠BclXL displays structural features characteristic of a molten globule under acidic pH. ⺠Membrane insertion of BclXL is favored under acidic pH. ⺠Ligand binding to BclXL is compromised under acidic and alkaline pH.
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Authors
Vikas Bhat, Dmitry Kurouski, Max B. Olenick, Caleb B. McDonald, David C. Mikles, Brian J. Deegan, Kenneth L. Seldeen, Igor K. Lednev, Amjad Farooq,