| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925496 | Archives of Biochemistry and Biophysics | 2012 | 8 Pages |
Abstract
⺠Homologous proteins were used for reconstitution in our functional assay. ⺠Ala/Asp substitutions were introduced at Ser23/24 of cardiac troponin I (cTnI). ⺠Protein kinase A phosphorylation was mimicked using Asp substitutions in cTnI. ⺠Ala/Asp substitutions at Ser23/24 of cTnI decreased the thin filament activation. ⺠Ca2+ sensitivity decreased with Asp substitutions, but not with Ala substitutions.
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Authors
Ranganath Mamidi, Sampath K. Gollapudi, Sri Lakshmi Mallampalli, Murali Chandra,