| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925537 | Archives of Biochemistry and Biophysics | 2012 | 7 Pages |
Abstract
Bioactivation of vitamin D3 involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.
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Authors
Jinge Zhu, Hector F. DeLuca,