| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925628 | Archives of Biochemistry and Biophysics | 2012 | 8 Pages |
Abstract
⺠Our proteomic screening detected the interaction of VHL and HP1. ⺠We identified a conserved HP1-binding motif (PXVXL) in VHL. ⺠This HP1-binding motif is disrupted in renal carcinoma-associated VHL P81S mutant. ⺠VHL P81S mutant displays reduced HP1 interaction, but is able to degrade HIF-α. ⺠HP1 increased the chromatin association of VHL30.
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Authors
Yanlai Lai, Meihua Song, Kevin Hakala, Susan T. Weintraub, Yuzuru Shiio,