| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925729 | Archives of Biochemistry and Biophysics | 2011 | 8 Pages |
Abstract
Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.
► Review of regulation of ciliary and flagellar motility by phosphorylation. ► Kinases and phosphatases anchored in the ciliary axoneme. ► Proteomic studies identifying ciliary proteins and phosphoprotein substrates.
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Authors
Maureen Wirschell, Ryosuke Yamamoto, Lea Alford, Avanti Gokhale, Anne Gaillard, Winfield S. Sale,