Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1925795 | Archives of Biochemistry and Biophysics | 2011 | 7 Pages |
Abstract
⺠Replacing Tyr7 in the active site of human carbonic anhydrase II enhanced proton transfer in catalysis. ⺠Replacement of Try7 caused reduced thermal stability. ⺠Replacement of Tyr7 with Ile caused a conformational change at the amino terminus. ⺠Results demonstrate a role for Tyr7 in folding and stability for carbonic anhydrases in the α class.
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Authors
Rose Mikulski, Balendu Sankara Avvaru, Chingkuang Tu, Nicolette Case, Robert McKenna, David N. Silverman,