| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925819 | Archives of Biochemistry and Biophysics | 2011 | 9 Pages |
Abstract
⺠Thr302 is susceptible to mechanism-based inactivation by aryl acetylenes. ⺠Thr302 forms an ester adduct with the reactive intermediate of tBPA, leading to the inactivation of P450 2Bs. ⺠tBPA is a potent mechanism-based inactivator of P450 2Bs because of its unique binding mode in the active site of P450 2Bs. ⺠This unique binding mode of tBPA in CYP2Bs may serve as a basis for designing more specific inhibitors for P450s.
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Authors
Haoming Zhang, Hsia-lien Lin, Cesar Kenaan, Paul F. Hollenberg,