Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1926651 | Archives of Biochemistry and Biophysics | 2008 | 9 Pages |
Abstract
Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000-fold concentration gradient across the membrane. Its crystal structures have been determined for nine different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, which is achieved by a series of very large domain rearrangements.
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Authors
Chikashi Toyoshima,