| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1927011 | Archives of Biochemistry and Biophysics | 2007 | 5 Pages |
Abstract
This review focusses on our current knowledge of the mechanisms employed by embryonic stem (ES) cells to avoid destruction by cell-mediated immune responses. Recently, ES cells have been found to shield themselves against cytotoxic effector cells by expressing CD95L and serine protease inhibitor SPI-6 mediating apoptosis of the cytotoxic cells and inactivation of granzyme B, respectively. These findings are discussed in view of their implications for using ES cell-derived transplants in regenerative medicine as well as for our understanding of early embryonic stages during invasion and implantation.
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Authors
Olaf Utermöhlen, Martin Krönke,