Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1927523 | Archives of Biochemistry and Biophysics | 2006 | 7 Pages |
Abstract
Complex I in bovine heart submitochondrial particles catalyses the NADH-supported generation of superoxide anion; adrenaline is oxidised by superoxide to adrenochrome that, on its hand, is reduced by Complex I, thus establishing a redox cycle that amplifies the superoxide production. The routes in Complex I for superoxide formation and for adrenochrome reduction appear to be different, since they have a different sensitivity to Complex I inhibitors. The results are discussed in terms of current assays for superoxide detection and of pathologies linked to catecholamine oxidation.
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Authors
Maria Luisa Genova, Nagwa M. Abd-Elsalam, El Sayed M.E. Mahdy, Andrea Bernacchia, Marco Lucarini, Gian Franco Pedulli, Giorgio Lenaz,