| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1928642 | Biochemical and Biophysical Research Communications | 2013 | 7 Pages |
Abstract
- Hypericin-photodynamic therapy induces phox-ER stress both in vitro and in vivo.
- Phox-ER stress activates PERK and CHOP.
- Phox-ER stress causes up-regulation of BH3-only proteins, Bim and Noxa.
- Noxa, but not Bim, contributes toward phox-ER stress induced apoptosis.
- PERK regulates Noxa in a CHOP-independent, temporally-defined manner.
Keywords
eIF2aMEFGRP78UPRC/EBP homologous proteinROSEndoplasmic reticulum stressCHOPApoptosisPhotodynamic therapy (PDT)ICDBladder cancerendoplasmic reticulumPhoxmurine embryonic fibroblastBIMCell deathImmunogenic cell deathHypericinUnfolded protein responsePERKglucose regulated protein 78Reactive oxygen species
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Authors
Tom Verfaillie, Alexander van Vliet, Abhishek D. Garg, Michael Dewaele, Noemi Rubio, Sanjeev Gupta, Peter de Witte, Afshin Samali, Patrizia Agostinis,