| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1928885 | Biochemical and Biophysical Research Communications | 2013 | 7 Pages |
Abstract
⺠Paclitaxel can overcome the resistance of Bcl-2 to apoptosis depending on dosage. ⺠Bcl-2 inhibits ER calcium release, which contributes to its apoptosis resistance. ⺠Paclitaxel stimulates pro-apoptotic ER calcium release in the presence of Bcl-2. ⺠Paclitaxel overcomes Bcl-2's inhibition on basal ER calcium release.
Keywords
HSDBcl-2ThapsigarginHRPFITCATCCCCEDMSOROSFluorescence resonance energy transferFRETstandard deviationANOVAhonestly significant differenceApoptosisRoom temperatureDimethyl sulfoxideBreast cancerendoplasmic reticulumfluorescein isothiocyanateSERCACapacitative calcium entryPaclitaxelHorseradish peroxidasePropidium iodideCalciumReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Zhi Pan, Lauren Gollahon,