A single E105K mutation far from the active site of influenza B virus neuraminidase contributes to reduced susceptibility to multiple neuraminidase-inhibitor drugs

Article ID	Journal	Published Year	Pages	File Type
1928999	Biochemical and Biophysical Research Communications	2012	6 Pages	PDF

Abstract

âº E105K mutation in influenza B virus NA confers reduced susceptibility to NA inhibitors. âº Residue 105 is located far from the enzymatic active site of NA. âº E105K mutation may destabilize the tetrameric form of NA.

Keywords

3D structure Influenza B virus

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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A single E105K mutation far from the active site of influenza B virus neuraminidase contributes to reduced susceptibility to multiple neuraminidase-inhibitor drugs

Authors

Seiichiro Fujisaki, Emi Takashita, Masaru Yokoyama, Tae Taniwaki, Hong Xu, Noriko Kishida, Hironori Sato, Masato Tashiro, Masaki Imai, Takato Odagiri,