| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1929057 | Biochemical and Biophysical Research Communications | 2012 | 4 Pages |
Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc. However, recent studies demonstrated that CyPA also possesses a repressive effect on the replication of some viruses like Influenza A virus and rotavirus. Moreover, CyPA could also regulate host IFN-I response to viral infections. Together, these evidences showed diverse roles of CyPA in viral infection.
► CyPA plays a critical role in the successful replication of viruses. ► CyPA also possesses a repressive effect on the replication of some viruses. ► CyPA could also regulate host IFN-I response to viral infections.
