| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1929206 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠p53-Mdm2 complex is a interesting target for anticancer drug design. ⺠We tried to gain information on apo and inhibitor bound forms by means MD simulations. ⺠IMZ caused principal changes in the β-sheets surrounding the binding cleft (β2â²). ⺠BDZ produced its most significant changes in the antiparallel β-sheets.
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Authors
Anna Maria Almerico, Marco Tutone, Licia Pantano, Antonino Lauria,