Article ID Journal Published Year Pages File Type
1929582 Biochemical and Biophysical Research Communications 2012 5 Pages PDF
Abstract
► Hypoxia induces ARC mRNA and protein expression in colon cancer cells. ► HIF-1 mediates hypoxia-induced ARC expression. ► HIF-1α activates ARC expression by binding to its promoter region. ► Hypoxia-inhibited Bax translocation during TRAIL-induced cell death was mediated by ARC.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Hypoxia-inducible Factor 1 regulated ARC expression mediated hypoxia induced inactivation of the intrinsic death pathway in p53 deficient human colon cancer cells
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