Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition

Article ID	Journal	Published Year	Pages	File Type
1929646	Biochemical and Biophysical Research Communications	2012	6 Pages	PDF

Abstract

âº Short-chain ceramides sensitize genistein-induced melanoma apoptosis. âº PDMP and SKI-II facilitates genistein-induced ceramides production and apoptosis. âº JNK activation and Akt inhibition mediates ceramides and genistein-induced apoptosis.

Keywords

FACS 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol DMEM Jnk FBS SphK1 mTOR PDMP MAPK Dulbecco’s modified Eagle medium MTT Sphingosine kinase-1 Melanoma fluorescence-activated cell sorting ceramides fetal bovine serum combination index Genistein mammalian target of rapamycin mitogen activated protein kinase Propidium iodide

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition

Authors

Chao Ji, Yan-li Yang, Li He, Bing Gu, Ji-ping Xia, Wei-ling Sun, Zhong-lan Su, Bin Chen, Zhi-gang Bi,