| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1929709 | Biochemical and Biophysical Research Communications | 2012 | 4 Pages |
ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate. Acetyl-CoA is a vital building block for the endogenous biosynthesis of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications. Acetyl-CoA is also required for acetylation reactions that modify proteins such as histone acetylation. In the present review some of the known features of ACLY such as tissue distribution, subcellular localization, enzymatic properties, gene regulation and associated physiological conditions are highlighted.
► ACLY is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate. ► ACLY is associated with different physiological conditions. ► This review highlights the current findings regarding ACLY.
