| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1929730 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Prolonged culture expansion retards proliferation and induces senescence of hBMSCs. ⺠Reduced 20S proteasomal activity and expression potentially contribute to cell aging. ⺠MG132-mediated 20S proteasomal inhibition induces senescence-like phenotype. ⺠18α-GA stimulates proteasomal activity and restores replicative senescence. ⺠18α-GA retains differentiation without affecting stem cell characterizations.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Li Lu, Hui-Fang Song, Wei-Guo Zhang, Xue-Qin Liu, Qian Zhu, Xiao-Long Cheng, Gui-Jiao Yang, Ang Li, Zhi-Cheng Xiao,