| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930002 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
It is well known that exercise prevents and reduces cognitive impairment. In the present study, we focused on exercise training as a tool to prevent cognitive impairment, and searched for novel molecules that may relate to the prevention of cognitive impairment in the hippocampus. Two-month-old senescence-accelerated mouse prone-8 (SAMP8) mice were subjected to voluntary exercise training by running on a wheel for 4 months, and were then assigned a conditioned fear memory test. Moreover, various mRNA levels in the hippocampus were examined by DNA array analysis and real-time PCR. Contextual fear memory in SAMP8 control mice was significantly impaired compared with that in non-senescence mice. Exercise training definitely attenuated such cognitive impairment. The results of real-time PCR analysis that was conducted following DNA array analysis in the hippocampus revealed that, compared with SAMR8 control mice, the expression levels of leucine zipper transcription factor-like protein 1 (Lztfl1) mRNA were significantly higher in SAMP8 mice subjected to exercise training. In addition, the overexpression of Lztfl1 promoted neurite outgrowth in Neuro 2a cells. These results suggest that exercise has a preventive effect on cognitive impairment in SAMP8 mice, and that exercise-induced increase in Lztfl1 induces neurite outgrowth.
► We examined effects of exercise training on cognitive impairment in SAMP8 mice. ► Exercise training attenuated impaired contextual fear memory in SAMP8 mice. ► Expression of the Lztfl1 mRNA in hippocampus was upregulated by exercise training. ► The overexpression of Lztfl1 promoted neurite outgrowth in Neuro 2a cells. ► Exercise induced increase in Lztfl1 is thought to indicate neurite outgrowth.
