Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1930029 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Low dose CP-690,550 (tofacitinib) inhibited CIA but accelerated EAE models. ⺠Low dose CP-690550 inhibited Th1 and Th2 but enhanced Th17 development. ⺠Low dose CP-690,550 inhibited STAT1,5,6 but not STAT3 phosphorylation. ⺠CP-690,550 inhibits JAK1 less efficiently than JAK3 in vivo.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Hideyuki Yoshida, Akihiro Kimura, Tomohiro Fukaya, Takashi Sekiya, Rimpei Morita, Takashi Shichita, Hiromasa Inoue, Akihiko Yoshimura,