| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930175 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠TCR recognize complexes between HLA and peptides derived from intracellular proteins. ⺠We used alanine scanning to determine amino acids for binding to the peptide/HLA. ⺠Five substitutions decreased the binding affinity compared with that of wildtype TCR. ⺠One substitution improved the binding affinity compared with wildtype TCR. ⺠Our results provide fundamental information for constructing mutant TCRs.
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Authors
Shogo Narimatsu, Yasuo Yoshioka, Tomohiro Morishige, Xinglei Yao, Shin-ichi Tsunoda, Yasuo Tsutsumi, Michael I Nishimura, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa,