| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930234 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠SPK1 protein contains a conserved acetylation motif (the GK motif). ⺠Lysine acetylation is an important regulatory manner of SPK1 protein. ⺠SPK1 is regulated by p300/CBP acetyltransferases. ⺠We show that acetylated SPK1 controls cell growth and cell-cycle progression.
Keywords
PTMS1PPGC-1αCBPRIPAPCAFsirtuinSIRTCREBPPARγHDACFOXO1GAPDHHEKTCAeGFPFBSSPKTSAPVDFPBSperoxisome proliferator-activated receptor gamma coactivator 1-alphaAdenovirusAcetylationacetyl coenzyme AAcetyl-CoASphingosine kinaseSphingosine kinase 1sphingosine 1-phosphatetricarboxylic acidsodium dodecyl sulfate–polyacrylamide gel electrophoresisSDS-PAGEstandard deviationImmunoprecipitationTrichostatin AProtein modificationsForkhead box O1Cell growthfetal bovine serumradioimmunoprecipitation assayP300/CBP-associated factorPhosphate-buffered salineNADNAD, nicotinamide adenine dinucleotidehemagglutininhistone deacetylasesHistone acetyltransferaseCREB-binding proteinenhanced green fluorescent proteincAMP-response element-binding proteinPolyvinylidene fluorideCell-cycle progressionHAThuman embryonic kidneyPeroxisome proliferator-activated receptor gammaglyceraldehyde 3-phosphate dehydrogenaseUbiquitin
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Authors
Hongyang Yu, Yong Shao, Lihua Gao, Liancheng Zhang, Kanghe Guo, Chutse Wu, Xianwen Hu, Haifeng Duan,