| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930343 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠We examined the role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. ⺠Elder Nrf2-knockout mice have age-related hearing loss. ⺠Hair cell loss caused by gentamicin treatment was enhanced in the Nrf2-deficient tissues. ⺠The responses of Nrf2-target genes by gentamicin were reduced in Nrf2-knockout mice.
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Authors
Tomofumi Hoshino, Keiji Tabuchi, Bungo Nishimura, Shuho Tanaka, Masahiro Nakayama, Tetsuro Ishii, Eiji Warabi, Toru Yanagawa, Ritsuku Shimizu, Masayuki Yamamoto, Akira Hara,