| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930507 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The cell culture system with recombinant HCV replaced with NS5A was developed. ⺠Recombinant HCV with NS5A of genotype 2 strains showed efficient virus assembly. ⺠Mutations at the C-terminus of NS5A were responsible for the efficient virus assembly. ⺠Recombinant HCV with genotype 1 strains were susceptible to the NS5A inhibitor. ⺠Recombinant HCV with genotype 2 strains were resistant to the NS5A inhibitor.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yuka Okamoto, Takahiro Masaki, Asako Murayama, Tsubasa Munakata, Akio Nomoto, Shingo Nakamoto, Osamu Yokosuka, Haruo Watanabe, Takaji Wakita, Takanobu Kato,