| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930573 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠A strategy to increase cytoprotective gene expression in injured tissue is outlined. ⺠A peptide containing a DEETGE motif can increase Nrf2 responsive genes in vivo. ⺠Gene expression in injured brains requires a calpain cleavage site. ⺠This peptide decreases BBB compromise when infused pre- or post-brain injury. ⺠Cleavage sites for disease-specific proteases could be used to treat that condition.
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Authors
Jing Zhao, John B. Redell, Anthony N. Moore, Pramod K. Dash,