Solution X-ray scattering study of a full-length class A penicillin-binding protein

Article ID	Journal	Published Year	Pages	File Type
1930618	Biochemical and Biophysical Research Communications	2011	5 Pages	PDF

Abstract

âº We generated a model of full-length PBP1b from Streptococcus pneumoniae in solution. âº We first modeled ab initio the glycosyltransferase domain using dummy residues. âº We then used (Ï, Ï) refinement starting from a homology model of full-length PBP1b. âº Both methods show that the two catalytic domains do not have any direct contact. âº Our analysis suggests the existence of interdomain mobility of limited amplitude.

Keywords

Bacterial pathogenesis small angle X-ray Scattering penicillin binding protein Glycosyltransferase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Solution X-ray scattering study of a full-length class A penicillin-binding protein

Authors

P. Macheboeuf, M. Piuzzi, S. Finet, F. Bontems, J. Pérez, A. Dessen, P. Vachette,