| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930649 | Biochemical and Biophysical Research Communications | 2011 | 4 Pages |
Background: Overlaps in clinical, pathological and molecular characteristics of Parkinson’s disease (PD) and Major Depressive Disorder (MD-D) have promoted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. Experimental and clinical data suggest that genetic variations in Brain-derived neurotrophic factor (BDNF) gene may increase the risk for PD and MD-D. Methods: Two hundred and sixty-six PD, 83 MD-D and 400 controls were recruited for this study, assessed using a battery of neuropsychological tests, and genotyped for 11757C/G, 712A/G, 196A/G, and 270C/T in BDNF gene. Results: 712A/G was associated with 2.50-fold time risk of PD. By combining genotypes AG/AA with 712 GG genotype as reference (OR = 1) in stratification analysis, AG/AA genotypes were associated with PD (OR = 2.94, 95% CI = 1.88–4.61). Accordingly, the A allele was significantly overrepresented in PD compared with the G allele (OR = 3.16, 95% CI = 2.08–4.81). This distribution in females and males were similar. Conclusion: Our results suggested a novel association between BDNF 712A/G AG/AA genotypes and PD in a Chinese Han population.
► This is an interdisciplinary study which combines neurology and psychiatry. ► The association between AG/AA genotypes of 712A/G in Brain-derived neurotrophic factor and Parkinson’s disease, rather than Major Depressive Disorder, was established in a Chinese Han population for the first time in the present study. ► Considering the unknown etiology of Parkinson’s disease, original findings herein will be contributive in this field.
