| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930672 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠We identified changes in the expression and function of EGFR by anti-MUC1 antibody. ⺠An anti-MUC1 antibody GP1.4 decreased EGFR from cell surface by internalization. ⺠GP1.4 specifically inhibited ERK signaling triggered EGF-EGFR signaling pathway. ⺠Internalization of EGFR was dependent on the presence of MUC1 on cell surface. ⺠GP1.4 significantly inhibited EGF-dependent cancer cell proliferation and migration.
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Authors
Akinori Hisatsune, Hideki Nakayama, Mitsuru Kawasaki, Ichiro Horie, Takeshi Miyata, Yoichiro Isohama, Kwang Chul Kim, Hiroshi Katsuki,