| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930691 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Eye lens α-crystallin (AC) is a heteropolymer with αA and αB subunits in 3:1 ratio. ⺠α-Crystallin prevents the aggregation of other lens proteins. ⺠At high temperatures αB aggregates and also enhances the aggregation of β-crystallin. ⺠αA-Crystallin, but not a mutant αA-crystallin, reduced coaggregation of αB- and β-crystallin. ⺠The data provide a basis for α-crystallin with a specific αA to αB ratio to maintain eye lens transparency.
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Authors
P.N. Srinivas, Madhoosudan A. Patil, G. Bhanuprakash Reddy,