| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930694 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠2B4+ CD8+ T cells stimulated with HIV peptides show reduced IFN-γ secretion. ⺠Cytolytic activity of 2B4+ CD8+ T cells is inhibited by HIV peptide stimulation. ⺠SAP, an adaptor molecule is downregulated in HIV peptide stimulated 2B4+ CD8+ T cells. ⺠May be the reason for inability of Cytotoxic T Lymphocytes to control HIV replication and disease progression.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Kim N. Aldy, Nathan C. Horton, Porunelloor A. Mathew, Stephen O. Mathew,