| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930787 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠We established TrkA-inducible U2OS cells stably expressing GFP-H2AX proteins. ⺠GFP-H2AX was colocalized with TrkA in the cytoplasm. ⺠γH2AX production was significantly increased upon activation of TrkA and suppressed by TrkA inhibitor or JNK inhibitor. ⺠Ectopic expression of H2AX promoted TrkA-mediated cell death through the modulation of TrkA tyrosine-490 phosphorylation and JNK activity upon DNA damage.
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Authors
Eun Joo Jung, Deok Ryong Kim,