Article ID Journal Published Year Pages File Type
1930901 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► We cloned, sequenced and analyzed the tirandamycin gene cluster. ► Seven genes were disrupted to support the tirandamycin biosynthetic pathway. ► TrdH as a positive regulator and TrdK as a negative regulator were identified. ► Inactivation of TrdI resulted in accumulation of two products. ► A model for tirandamycin biosynthesis is proposed.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666
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