| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1930956 | Biochemical and Biophysical Research Communications | 2010 | 7 Pages |
Abstract
⺠We have described for the first time the RAG-dependent recombination in the region dense in breakpoints within TEL and AML1 gene loci associated with t(12;21)(p13;q22) chromosomal translocation by an extrachromosomal recombination assay. ⺠We have found several heptamer-like sequences in the vicinity of RAG-dependent breakpoints at the TEL and AML1 translocation region. ⺠We have found that RAG proteins bind to and introduce DSBs into the nucleosomal TEL translocation region dense in TEL-AML1 breakpoints.
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Authors
Masashi Numata, Shoko Saito, Kyosuke Nagata,