| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1931022 | Biochemical and Biophysical Research Communications | 2011 | 4 Pages |
ObjectiveTo investigate whether the serum miR-221 expression correlates with clinicopathologic features and the prognosis of hepatocellular carcinoma (HCC) patients.MethodsFour miRNAs (miR-221, miR-222, miR-21 and miR-224) related to HCC were selected in the present study. Serum miRNA expression was investigated in 46 HCC patients and 20 healthy normal controls by using real-time PCR technique, and then correlations between miR-221 expression and the clinicopathological features and prognosis of HCC patients were evaluated.ResultsThe four miRNAs were found to be differentially overexpressed in HCC serum samples, and high level of miR-221 expression was correlated with tumor size (P < 0.001), cirrhosis (P = 0.003) and tumor stage (P = 0.016). In addition, Kaplan–Meier survival analysis showed that the overall survival rate of the high miR-221 expression group (27.6%) was significantly lower than that of the low miR-221 expression group (62.3%, P < 0.05).ConclusionsSerum miR-221, upregulated in HCC, can provide predictive significance for prognosis of HCC patients.
Research highlights► Serum miRNA expression was investigated in 46 HCC patients. ► Correlations between miR-221 expression and the clinical features were evaluated. ► miR-221 expression was correlated with tumor size, cirrhosis and tumor stage. ► Serum miR-221 can provide predictive significance for prognosis of HCC patients.
