Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression

► MMP-9 plays a pivotal role in the invasion of MCF-7 breast cancer cells. ► TPA stimulates MMP-9 expression through activation of MAPK/NF-κB and MAPK/AP-1 pathways. ► Dihydroavenanthramide D suppresses MMP-9 expression via inhibition of TPA-induced MAPK/NF-κB and MAPK/AP-1 activations. ► Dihydroavenanthramide D blocks cell invasion of MCF-7 breast cancer cells.