Article ID Journal Published Year Pages File Type
1931176 Biochemical and Biophysical Research Communications 2011 5 Pages PDF
Abstract
► The GCN5-deficiency remarkably causes apoptosis by H2O2 in chicken DT40 cells. ► Gene expressions of Syk and Btk are remarkably decreased in GCN5-deficient cells. ► H2O2-induced Akt phosphorylation is remarkably suppressed in GCN5-deficient cells. ► GCN5 binds to the proximal 5′-upstream regions of Syk and Btk genes in vivo. ► GCN5 plays a key role in epigenetic regulation of PI3K/Akt survival pathway.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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