| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1931238 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠Transient receptor potential vanilloid type 1 (TRPV1) channels may cause heart hypertrophy. ⺠TRPV1 transcripts were increased in transgenic mice overexpressing the catalytic subunit alpha of protein phosphatase 2A alpha (PP2Ac alpha). ⺠Discoidin domain receptor family, member 2 was significantly higher in PP2Ac compared to wild-type mice and TRPV1 knockout mice. ⺠The expression of miR21 was significantly higher in PP2Ac alpha compared with TRPV1 knockout mice. ⺠The study suggests an important role of TRPV1 in the pathogenesis of genetically associated heart hypertrophy.
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Authors
Florian Thilo, Ying Liu, Nico Schulz, Ulrich Gergs, Joachim Neumann, Christoph Loddenkemper, Maik Gollasch, Martin Tepel,