Article ID Journal Published Year Pages File Type
1931614 Biochemical and Biophysical Research Communications 2010 4 Pages PDF
Abstract

β-Hairpins, triple-strand β-sheets and βαβ-units represent simple structural motifs closed into cycles by systems of hydrogen bonds. Secondary closing of these simple motifs into large cycles by means of different superhelices, split β-hairpins or SS-bridges results in the formation of more complex structural motifs having unique overall folds and unique handedness such as abcd-units, φφ-motifs, five- and seven-segment α/β-motifs. Apparently, the complex structural motifs are more cooperative and stable and this may be one of the main reasons of high frequencies of occurrence of the motifs in proteins.

Research highlights► β-Hairpins and βαβ-units represent simple motifs closed into cycles by H-bonds. ► Secondary closing of the simple motifs results in unique structural motifs. ► One of the two forms of β-hairpins and triple-strand β-sheets is selected. ► Apparently, secondary closing results in more cooperative and stable motifs.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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