| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1931637 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
⺠AMPK regulates lipid metabolism (cholesterol and sphingomyelin) in response to cellular and body energy states. ⺠Inactivation of AMPK may elevate neuronal cholesterol and sphingomyelin levels and increased APP distribution in lipid rafts. ⺠The increased APP distribution in lipid rafts causes an increased APP processing by β-secretase (BACE) and Aβ generation. ⺠Therefore, activation of neuronal AMPK may be beneficial for controlling Aβ generation.
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Authors
Je-Seong Won, Yeong-Bin Im, Jinsu Kim, Avtar K. Singh, Inderjit Singh,