Article ID Journal Published Year Pages File Type
1931659 Biochemical and Biophysical Research Communications 2010 6 Pages PDF
Abstract
► HPV16 E5 downregulates an important stress signaling pathway: decreases spliced XBP-1 mRNA and IREα in human genital keratinocytes. ► HPV16 E5 decreases expression of COX-2 (downstream of XBP-1). ► Co-expression of the HPV-16 E6E7 genes partially alters the E5 phenotype. HPV-16 E5 cannot inhibit chemically-induced ER stress.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes
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