Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1931769 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
CUGBP1 is an RNA-binding protein controlling alternative splicing, mRNA translation and stability. In this work we used a motif scoring approach to identify putative CUGBP1 binding sites for genes located on the human chromosome 12. This allowed us to identify the gene CD9 as a presumptive target for CUGBP1-mediated regulation. In a number of cancers, the tetraspanin CD9 is down-regulated, an event correlated with a bad prognostic. Using a combination of biochemical approaches and CUGBP1 knockdown, we showed that CUGBP1 directly controls CD9 expression.
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Authors
Olivier Le Tonquèze, Bernhard Gschloessl, Allen Namanda-Vanderbeken, Vincent Legagneux, Luc Paillard, Yann Audic,