Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner

Article ID	Journal	Published Year	Pages	File Type
1931774	Biochemical and Biophysical Research Communications	2010	6 Pages	PDF

Abstract

rhALR and EGF induce different kinetics of ERK and Akt phosphorylation in human hepatocytes. The mitogenic effect of rhALR is liver specific and seems to be at least partially independent from EGF receptor mediated signaling.

Keywords

EGF Liver specificity Jab1 PHH HGF TGFα AP-1 FCS MTS LPS 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium ERK1/2 primary human hepatocytes Akt/PKB Liver regeneration transforming growth factor alpha Augmenter of liver regeneration fetal calf serum epidermal growth factor Hepatocyte growth factor lipopolysaccharide Human hepatocytes Partial hepatectomy activator protein-1 protein kinase B mitogen-activated protein kinase mitogen-activated protein kinase kinase extracellular signal-regulated kinase 1/2 MAP kinase