Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1932022 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
The biological roles of the dual oxidases, DUOX1 and DUOX2, are dependent upon the tissue in which they are expressed. However, the mechanisms that control DUOX expression in these tissues are largely unexplored. Given the known role of DUOX for host defense in the gut and respiratory tract, we characterized potential mechanisms that control DUOX2 expression in response to interferon gamma (IFNγ) in respiratory tract epithelium. We discovered that IFNγ-mediated DUOX2 expression was regulated by a STAT-independent, JAK-independent pathway. These data provide insights into a novel IFNγ signaling pathway with potential importance for regulation of host defense responses.
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Authors
Thomas Hill III, Changhong Xu, Richart W. Harper,