Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1932373 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
This communication describes the application of a modified sandwich enzyme-linked immunosorbent assay (ELISA), termed Multimer Detection System (MDS) for the detection of disease-associated multimeric forms of the prion protein (PrPd) in hamster blood. PrPd was detected in plasma of prion-affected hamsters while MDS revealed no PrPd in identically-treated plasma of healthy animals. This is the first report of a single ELISA- based immune detection of PrPd from blood samples.
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Authors
S.S.A. An, K.T. Lim, H.J. Oh, B.S. Lee, E. Zukic, Y.R. Ju, T. Yokoyama, S.Y. Kim, E. Welker,