| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1932598 | Biochemical and Biophysical Research Communications | 2009 | 4 Pages |
Abstract
The neuraminidase inhibitor oseltamivir has been identified to have significant anti-influenza activity in clinical practice. However, its efficacy has not been verified in enough subtypes of influenza A virus, particularly, the current pandemic virus, H1N1. In vitro, using our influenza pseudotyped particle system, oseltamivir displayed significant inhibitory effects on viral NA activity and pp release. Conversely, a boosting effect on viral infection was observed, particularly with the 2009 H1N1 pp at oseltamivir concentrations above 0.025 μM. Further testing on two wild 2009 H1N1 virus strains, A/California/07/09 and A/Sichuan/1/09, as well as a seasonal flu virus, A/Baoan/51/2008, confirmed these findings.
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Authors
Xiaojing Lin, Jianfang Zhou, Yonghui Zhang, Jia Wu, Fengwei Zhang, Zi Li, Ye Zhang, Shengli Bi, Yuelong Shu, Yue Wang,