Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1932645 | Biochemical and Biophysical Research Communications | 2010 | 4 Pages |
Abstract
Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C12(EO)21) (HL-21), were rapidly accumulated in the membrane of PEL cells. HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death. These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.
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Authors
Tomomi Towata, Yuji Komizu, Shinya Suzu, Ryuichi Ueoka, Seiji Okada,