| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1932747 | Biochemical and Biophysical Research Communications | 2009 | 5 Pages |
Abstract
HLTF is highly similar in domain organisation to yeast Rad5. We identify PTIP and RPA70, both involved in DNA replication and DNA repair, as HLTF-interacting proteins although cells depleted of HLTF did not show defects in cellular responses to DNA damage. In vitro, HLTF has ATPase activity and E3 ubiquitin ligase activity with a range of E2 ubiquitin conjugating enzymes. HLTF expression is severely reduced in a range of cancer cells, and we suggest that the HLTF antibodies generated in this study could be used for cancer diagnostic purposes.
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Authors
Craig MacKay, Rachel Toth, John Rouse,